Xenical it is effective in respect of long control of weight of a body (decrease in weight of a body and its maintenance at new level, prevention of a repeated increase of weight of a body). Treatment by Ksenikalom leads to improvement of a profile of risk factors and the diseases accompanying adiposity, including a hypercholesterolemia, type 2 diabetes (ИНЗСД), tolerance infringement to glucose, гиперинсулинемию, an arterial hypertensia, and to quantity reduction висцерального fat. At use in a combination with such сахароснижающими preparations as метформин, preparations сульфонилмочевины and-or insulin at sick of a diabetes of type 2 with in superfluous weight of a body (ИМТ≥28 kg/m2) or adiposity (ИМТ≥30 kg/m2) Ksenikal, in a combination to moderately hypohigh-calorie diet, gives additional improvement of indemnification of a carbohydrate exchange. In clinical researches at the majority of patients of concentration of vitamins A, D, E, To and beta carotin during two full years of therapy орлистатом remained within norm. For maintenance of adequate receipt of all nutrients it is possible to appoint polyvitamins. The patient should receive the balanced, moderately hypohigh-calorie diet containing no more of 30 % of food value in the form of fats. A food rich with fruit and vegetables Is recommended. Daily consumption of fats, carbohydrates and fibers is necessary for distributing on three basic receptions. The probability of collateral reactions from party ZHKT can increase, if Ksenikal accept against a food rich with fats (for example 2000 kcal/sut, from them more than 30 % in the form of fats that equals approximately 67 г fat). Daily consumption of fats should be distributed on three basic receptions. At sick of a diabetes of type 2 reduction of weight of a body at treatment by Ksenikalom is accompanied by improvement of indemnification of a carbohydrate exchange that presumes or to demand dose decrease сахароснижающих preparations.
Collateral reactions on орлистат arose, mainly, from party ZHKT and have been caused by pharmacological action of the preparation interfering an absorption of fats of food. Such phenomena, as oily allocation from a rectum, allocation of gases with a quantity separated, imperative desires on дефекацию, стеаторея, increase дефекации and an incontience кала were often marked.
Their frequency increases at increase of the maintenance of fat in food. Patients should be informed on possibility of occurrence of collateral reactions from party ZHKT and to train, how to eliminate them by the best observance of a diet, especially concerning quantity of fat containing in it. Application of a diet with the low maintenance of fat reduces probability of collateral actions from party ZHKT and by that helps patients to supervise and regulate consumption of fats.
As a rule, the specified collateral reactions are poorly expressed and транзиторными. They arose at early stages of treatment (in the first 3 мес), and at the majority of patients was no more than one episode of such reactions.
At treatment following undesirable phenomena from party ZHKT arise Ksenikalom often: pains or discomfort in a stomach, метеоризм, a liquid chair, “a soft” chair, pains or discomfort in a rectum, defeat of teeth, defeat of gums.
Infections of the top or bottom respiratory ways, a flu, headaches, дисменорея, alarm, weakness, infections мочевыводящих ways were marked also.
Rare occurences of allergic reactions are described, the itch, a rash, the small tortoiseshell, ангионевротический a hypostasis and анафилаксия were the main which clinical symptoms.
At sick of a diabetes of type 2 character and frequency of the undesirable phenomena were comparable to those at persons without a diabetes with superfluous weight of a body and adiposity. The unique new collateral actions arising with frequency> of 2 % and ≥1 %, in comparison with a placebo, were гипогликемические conditions (which improvement of indemnification of a carbohydrate exchange could result) and a stomach swelling.
